{"id":940,"date":"2022-09-15T10:01:56","date_gmt":"2022-09-15T14:01:56","guid":{"rendered":"https:\/\/medicamentquebec.ca\/?p=940"},"modified":"2025-12-05T15:03:55","modified_gmt":"2025-12-05T20:03:55","slug":"medicament-quebec-soutient-un-projet-pour-renforcer-lautonomie-du-quebec-en-production-de-medicaments-2","status":"publish","type":"post","link":"https:\/\/medicamentquebec.ca\/index.php\/2022\/09\/15\/medicament-quebec-soutient-un-projet-pour-renforcer-lautonomie-du-quebec-en-production-de-medicaments-2\/","title":{"rendered":"M\u00e9dicament Qu\u00e9bec soutient un projet pour renforcer l’autonomie du Qu\u00e9bec en production d’ingr\u00e9dients actifs et de m\u00e9dicaments"},"content":{"rendered":"\r\n

Activit\u00e9s financ\u00e9es – 15 septembre 2022<\/strong><\/p>\r\n

<\/p>\r\n\r\n\r\n\r\n

Dans le cadre de sa premi\u00e8re phase<\/strong>, M\u00e9dicament Qu\u00e9bec annonce l’octroi d’un financement de 2 041 500$ pour l\u2019activit\u00e9 \u00ab\u00a0Synth\u00e8se d\u2019ingr\u00e9dients actifs pour pallier \u00e0 une p\u00e9nurie ou une requ\u00eate du secteur du m\u00e9dicament\u00a0\u00bb<\/strong> qui sera dirig\u00e9e par Andr\u00e9 Charette<\/a>, professeur au D\u00e9partement de chimie de l\u2019Universit\u00e9 de Montr\u00e9al. Cette activit\u00e9 aura pour objectif d\u2019am\u00e9liorer la capacit\u00e9 du Qu\u00e9bec \u00e0 pallier \u00e0 des p\u00e9nuries potentielles de m\u00e9dicaments.<\/p>\r\n\r\n\r\n\r\n

En quoi consiste l’activit\u00e9?<\/strong><\/p>\r\n\r\n\r\n\r\n

Ce projet vise \u00e0 pallier ce probl\u00e8me en utilisant une nouvelle technique de pointe appel\u00e9e la synth\u00e8se en flux continu pour ultimement s\u00e9curiser un approvisionnement local. Contrairement aux r\u00e9acteurs de gros volumes classiques, cette technique permet la fabrication agile d’ingr\u00e9dients actifs sur demande tout en utilisant une technique ayant une empreinte \u00e9cologique tout \u00e0 fait compatible avec l’environnement. Cette initiative vise sp\u00e9cifiquement \u00e0 d\u00e9velopper les recettes d’ingr\u00e9dients actifs les plus susceptibles d’\u00eatre en p\u00e9nurie en utilisant la synth\u00e8se en flux continu.<\/p>\r\n\r\n\r\n\r\n

Ce processus consiste \u00e0 identifier les ingr\u00e9dients actifs qui sont en p\u00e9nurie maintenant ou qui le sont sur une base r\u00e9guli\u00e8re depuis une quinzaine d’ann\u00e9es (liste disponible sur le site de sant\u00e9 Canada; inquisitions dans le milieu hospitalier; int\u00e9r\u00eats sp\u00e9cifiques des pharmaceutiques qu\u00e9b\u00e9coises, arrimage avec les travaux du pilier 3, data mining IA). En fonction des besoins et de la complexit\u00e9 des mol\u00e9cules, une liste de priorit\u00e9s sera \u00e9tablie en collaboration du milieu preneur. Les voies de synth\u00e8se des ingr\u00e9dients actifs choisies seront \u00e9labor\u00e9es en gardant \u00e0 l’esprit trois crit\u00e8res importants : faisabilit\u00e9 \u00e0 court terme; minimisation des co\u00fbts de production (vs prix de vente actuel); et int\u00e9r\u00eat du transfert technologique vers une entreprise pour la mise en \u00e9chelle et la distribution (Kemitek, Delmar).<\/p>\r\n\r\n\r\n\r\n

\u00c0 moyen terme, des proc\u00e9dures de synth\u00e8se en flux continu d’ingr\u00e9dients actifs incluses dans la liste de priorit\u00e9s seront d\u00e9velopp\u00e9es et test\u00e9es sur une \u00e9chelle moyenne. Ultimement, il serait souhaitable que les proc\u00e9dures de fabrication en flux continu de tous les m\u00e9dicaments (g\u00e9n\u00e9riques) qui pourraient potentiellement \u00eatre en p\u00e9nurie soient disponibles pour que le Qu\u00e9bec puisse pallier rapidement \u00e0 un \u00e9ventuel probl\u00e8me d’approvisionnement. Le d\u00e9veloppement de certaines proc\u00e9dures pour la production de certains ingr\u00e9dients actifs sera fait conjointement avec des partenaires en fonction de leurs expertises et de leurs capacit\u00e9s commerciales. D’une part, le d\u00e9veloppement de certaines proc\u00e9dures n\u00e9cessite l’expertise et la collaboration de partenaires industriels, acad\u00e9miques et des CCTT (optimisation des voies de synth\u00e8se, design de r\u00e9acteurs, contr\u00f4le de qualit\u00e9 en ligne, etc.) afin de surmonter les d\u00e9fis qui se pr\u00e9senteront en fonction de la complexit\u00e9 des r\u00e9actions et des structures mol\u00e9culaires des mol\u00e9cules cibles. D\u2019autre part, en collaboration de la plateforme de biopharmacie, la validation et la mise au point d’une formule maitresse pour tous les m\u00e9dicaments prioris\u00e9s seront effectu\u00e9es.<\/p>\r\n\r\n\r\n\r\n

Pour en savoir plus > Un chimiste propose l’ind\u00e9pendance pharmaceutique du Cana<\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"

Dans le cadre de sa premi\u00e8re phase, M\u00e9dicament Qu\u00e9bec annonce l’octroi d’un financement de 2 041 500$ pour l\u2019activit\u00e9 \u00ab\u00a0Synth\u00e8se d\u2019ingr\u00e9dients actifs pour pallier \u00e0 une p\u00e9nurie ou une requ\u00eate du secteur du m\u00e9dicament\u00a0\u00bb qui sera dirig\u00e9e par Andr\u00e9 Charette, professeur au D\u00e9partement de chimie de l\u2019Universit\u00e9 de Montr\u00e9al. Cette activit\u00e9 aura pour objectif d\u2019am\u00e9liorer la capacit\u00e9 du Qu\u00e9bec \u00e0 pallier \u00e0 des p\u00e9nuries potentielles de m\u00e9dicaments.<\/p>\n","protected":false},"author":4,"featured_media":3140,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[85,96],"tags":[],"class_list":["post-940","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-pilliers"],"yoast_head":"\nM\u00e9dicament Qu\u00e9bec soutient un projet pour renforcer l'autonomie du Qu\u00e9bec en production d'ingr\u00e9dients actifs et de m\u00e9dicaments - M\u00e9dicament Qu\u00e9bec<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicamentquebec.ca\/index.php\/2022\/09\/15\/medicament-quebec-soutient-un-projet-pour-renforcer-lautonomie-du-quebec-en-production-de-medicaments-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M\u00e9dicament Qu\u00e9bec soutient un projet pour renforcer l'autonomie du Qu\u00e9bec en production d'ingr\u00e9dients actifs et de m\u00e9dicaments - M\u00e9dicament Qu\u00e9bec\" \/>\n<meta property=\"og:description\" content=\"Dans le cadre de sa premi\u00e8re phase, M\u00e9dicament Qu\u00e9bec annonce l'octroi d'un financement de 2 041 500$ pour l\u2019activit\u00e9 \u00ab\u00a0Synth\u00e8se d\u2019ingr\u00e9dients actifs pour pallier \u00e0 une p\u00e9nurie ou une requ\u00eate du secteur du m\u00e9dicament\u00a0\u00bb qui sera dirig\u00e9e par Andr\u00e9 Charette, professeur au D\u00e9partement de chimie de l\u2019Universit\u00e9 de Montr\u00e9al. 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